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α-Galactosylceramide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
α-Galactosylceramide图片
CAS NO:158021-47-7
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议

产品名称
α-GalCer
KRN7000
产品介绍
α-Galactosylceramide (α-GalCer) 是一种合成的糖脂,具有抗肿瘤和免疫刺激作用。α-Galactosylceramide 是一种非常有效的NKT细胞激动剂,可与 CD1d 有效结合。α-Galactosylceramide 与 CD1d 的复合物可与NKT细胞的 T 细胞抗原受体结合。
生物活性

α-Galactosylceramide (α-GalCer) is a synthetic glycolipid with antitumorial and immunostimulatory. α-Galactosylceramide is a very potentNKT cellagonist and binds effectively toCD1d. The complex of α-Galactosylceramide plusCD1dbinds theNKT cellTCR (T cell antigen receptor)[1][2][3][4].

IC50& Target

NKT cell[3]

体外研究
(In Vitro)

Culture supernatants of activated Vα24+NKT-cell cultures stimulated with α-Galactosylceramide pulsed monocyte-derived dendritic cells (Mo-DCs) exhibits antiproliferative activities against melanoma cells. This effect is predominantly due to release of IFN-γ, and to a lesser extent IL-12. Other cytokines, including IL-4 and IL-10, are released but these cytokines have less antiproliferative effects. Vα24+NKT-cells stimulated by α-Galactosylceramide-pulsed Mo-DCs have anti-tumour activities against human melanoma through antiproliferative effects exerted by soluble mediators[3].

体内研究
(In Vivo)

α-Galactosylceramide treatment can protect against spontaneous, carcinogen-, or oncogene-induced primary tumor formation in mice. Consistent with a prime role for IFN-γ in NKT cell-mediated tumor responses, a C-glycoside analog of α-Galactosylceramide that preferentially stimulated IFN-γ production is even more effective than α-Galactosylceramide at preventing metastases of the B16 melanoma[1].
Since α-Galactosylceramide shows a potent antitumor activity and stimulates the lymphocyte proliferation (LP) on allogeneic mixed lymphocyte reaction (MLR) in the mouse, α-Galactosylceramide is considered to be a nonspecific immunostimulating agent which is a biological response modifier[4].

Clinical Trial
分子量

858.34

性状

Solid

Formula

C50H99NO9

CAS 号

158021-47-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : 0.5 mg/mL(0.58 mM;ultrasonic and warming and heat to 60℃)