CAS NO: | 1217022-63-3 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | PTC-209 hydrobromide is a specificBMI-1inhibitor with anIC50of 0.5 μM in HEK293T cell line. PTC-209 hydrobromide irreversibly impairs colorectal cancer-initiating cells (CICs). PTC-209 hydrobromide shows potent anti-myeloma activity and impairs the tumor microenvironment[1][2]. | ||||||||
IC50& Target | IC50: 0.5 μM (BMI-1, in HT1080 tumor cells)[1] | ||||||||
体外研究 (In Vitro) | PTC-209 (0.01-10 μM; 24-72 hours) induces a concentration- and time-dependent decrease in the cellular viability of all cell lines tested[2]. Cell Viability Assay[2]
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体内研究 (In Vivo) | PTC-209 (60 mg/kg body weight; subcutaneously; once a day for 11 days) significantly reduces tumor volume[2].
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分子量 | 576.10 | ||||||||
Formula | C17H14Br3N5OS | ||||||||
CAS 号 | 1217022-63-3 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |