Ezabenlimab (BI-754091) is an anti-PD-1mAb with binding constant K_dvalue of 6 nM (CHO cells). Ezabenlimab blocks the interaction ofPD-1withPD-L1andPD-L2. Ezabenlimab increases interferon-γ secretion in T cells, and inhibits tumor growth in vivo^[1].

PD-1/PD-L1, PD-1/PD-L2, IFN-γ^[1]

Ezabenlimab inhibits the interaction of PD-1 to PD-L1 and PD-L2 in CHO cells with IC₉₀s of 4.14 nM and 3.98 nM, respectively; and inhibits the interaction of PD-1 to PD-L1 and PD-L2 in cynomolgus with IC₉₀s of 5.61 nM and 7.54 nM, respectively^[1].
Ezabenlimab increases IFN-γ secretion in primary human antigen-experienced CD3-positive T cells, with an EC₅₀value of 0.9 nM^[1].
Ezabenlimab (200 nM) has synergistic effect with BI 754111, resulting in further increase of IFN-γ secretion^[1].

Ezabenlimab (0.3-30 mg/kg; i.p.; single dose or twice per week or every 3 weeks) inhibits tumor progress and shows comparable anti-tumor activity in hPD-1 knock-in mouse model^[1].

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