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9-Hydroxyellipticine hydrochloride
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
9-Hydroxyellipticine hydrochloride图片
CAS NO:52238-35-4
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
9-Hydroxyellipticine hydrochloride 是Topo II和RyR的抑制剂。9-Hydroxyellipticine hydrochloride 具有抗肿瘤、抗氧化和释放儿茶酚胺的活性。 9-Hydroxyellipticine hydrochloride 对 Hela S-3 和293T 细胞的IC50值分别为1.6 μM 和1.2μM。
生物活性

9-Hydroxyellipticine hydrochloride is a inhibitor ofTopo IIandRyR. 9-Hydroxyellipticine hydrochloride exhibits antitumor, antioxidant and catecholamine-releasing activities. 9-Hydroxyellipticine hydrochloride exhibits IC50values of 1.6 μM and 1.2μM in Hela S-3 and 293T cells, respectively[1][2][3].

IC50& Target

Topoisomerase II

 

体外研究
(In Vitro)

9-Hydroxyellipticine (9HE) causes selective inhibition of p53 protein phospborylation in Lewis lung carcinoma and SW480 (human colon cancer cell line) in a concentration-dependent manner from 0.1 to 100 μM[4].

体内研究
(In Vivo)

9-Hydroxyellipticine (5 or 10 mg/kg, ip) results in chromosome clumping and sister chromatid exchange in murine bone marrow cells[1].

Animal Model:Three- to five-month-old C57B1/6 male mice[1].
Dosage:5 or 10 mg/kg.
Administration:IP.
Result:Resulted in chromosome clumping, chromatid aberrations, and micronuclei formation in murine bone marrow cells.
分子量

298.77

Formula

C17H15ClN2O

CAS 号

52238-35-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.