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Epirubicin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Epirubicin图片
CAS NO:56420-45-2
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
表柔比星
4'-Epidoxorubicin
产品介绍
Epirubicin (4'-Epidoxorubicin) 是阿霉素的半合成的 L-阿拉伯糖衍生物,能够抑制Topoisomerase,起到抗肿瘤的作用。Epirubicin 抑制 DNA 和 RNA 合成。Epirubicin 是一种 Forkhead box 蛋白 p3 (Foxp3) 抑制剂,可抑制调节性 T 细胞活性。
生物活性

Epirubicin (4'-Epidoxorubicin), a semisynthetic L-arabino derivative of doxorubicin, has an antineoplastic agent by inhibitingTopoisomerase[1]. Epirubicin inhibits DNA and RNA synthesis. Epirubicin is aForkhead box protein p3 (Foxp3)inhibitor and inhibits regulatory T cell activity[2].

IC50& Target[1]

Topoisomerase

 

体外研究
(In Vitro)

Epirubicin (4'-Epidoxorubicin), like doxorubicin, exerts its antitumor effects by complex with DNA, resulting in damage to DNA and interference with the synthesis of DNA, RNA, and proteins. Epirubicin may also affect the integrity and activity of cellular membranes. Maximal cell kill caused by Epirubicin occurs during the S phase of the cell cycle. With higher concentrations effects are also seen in early G2 as well as G1 and M phases[1].
Epirubicin display antineoplastic activity against most cancer cells. Epirubicin is cytotoxic to Hepatoma G2 cells with IC50of 1.6 μg/mL at 24 hr. 1.6 μg/mL Epirubicin induces apoptosis of Hep G2 cells, and higher activity of catalase by 50%, Se-dependent glutathione peroxidase by 110%, Cu, Zn-superoxide dismutase by 172% and Mn-superoxide dismutase by 135%. Epirbicin increases the cellular expression of NADPH-CYP 450 reductase, and reduces GST-π expression[3].

体内研究
(In Vivo)

Epirubicin (4'-Epidoxorubicin) are clinically active against a broad range of tumor types, including breast cancer, malignant lymphomas, soft tissue sarcomas, lung cancer, pleural mesothelioma, gastrointestinal cancer, head and neck cancer, ovarian cancer, prostatic carcinoma, transitional bladder carcinoma and so on[4].
Epirubicin at a dose of 3.5 mg/kg suppresses tumor mass of human breast tumor xenograft R-27 by 74.4 %[5].

Clinical Trial
分子量

543.52

Formula

C27H29NO11

CAS 号

56420-45-2

中文名称

表阿霉素;表柔比星

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.