JNJ-3790339

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JNJ-3790339

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

93076-87-0

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

JNJ-3790339，一种 Ritanserin (HY-10791) 类似物，是一种有效且具有选择性的二酰甘油激酶 (DGKα) 抑制剂，IC₅₀为 9.6 μM。JNJ-3790339 对恶性细胞有诱导毒性作用，并提高上调 T 细胞活化的能力。

生物活性

JNJ-3790339, aRitanserin(HY-10791) analog, is a potent and selectivediacylglycerol kinase (DGKα)inhibitor with anIC₅₀of 9.6 μM. JNJ-3790339 has induction of toxicity in malignant cells, and improves ability to upregulate T cell activation^[1].

IC₅₀& Target

IC₅₀: 9.6 μM (DGKα)^[1]

体外研究
(In Vitro)

JNJ-3790339 (5-40 μM; 48 h) exhibits cytotoxic efficacy against A375, U251 and Jurkat T^[1].
JNJ-3790339 (5 μM; 6 h) promotes activation of primary murine T cells^[1].

Cell Cytotoxicity Assay^[1]

Cell Line:	A375, U251 and Jurkat T
Concentration:	5, 15, 25 and 40 μM
Incubation Time:	48 h
Result:	Exhibited cytotoxic efficacy against cancer cells in a dose-dependent manner.

RT-PCR^[1]

Cell Line:	Jurkat T
Concentration:	5 μM
Incubation Time:	6 h
Result:	Displayed high activation response with significantly increased CD69 and TNFα expression.

分子量

483.67

Formula

C₃₀H₃₃N₃OS

CAS 号

93076-87-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.