GABAA receptor agent 4 (compound 1e) is a potentγ-GABAARantagonist with anK_iof 0.18 μM. GABAA receptor agent 4 efficiently rescues inhibition of T cell proliferation. GABAA receptor agent 4 has the immunomodulatory potential^[1].

K_i: 0.18 μM (γ-GABAAR)^[1]

GABAA receptor agent 4 (compound 1e) shows antagonist activity withIC₅₀s of 4.95, 0.195, 0.250, 1.95, 2.18, 7.56, 0.56, 0.54 μM for α1β2δ, α4β1δ, α4β2δ, α6β2δ, α1β2γ2, α2β2γ2, α3β2γ2, α5β2γ2 subtypes, respectively^[1].
GABAA receptor agent 4 (50 μM; 96 h) rescues inhibition of proliferation induced by alprazolam in both human PBMC and mouse splenocytes populations with minimal cell toxicity^[1].

272.39

C₁₇H₂₄N₂O

2035203-91-7

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.