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PD-1/PD-L1-IN-27
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PD-1/PD-L1-IN-27图片
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
PD-1/PD-L1-IN-27 是一种有效的PD-1/PD-L1抑制剂,IC50值为 134 nM。 PD-1/PD-L1-IN-27 具有低 T 细胞毒性的抗肿瘤作用。PD-1/PD-L1-IN-27 具有激活 CD8+T 细胞和减少 T 细胞耗竭的能力。
生物活性

PD-1/PD-L1-IN-27 is a potentPD-1/PD-L1inhibitor with anIC50value of 134 nM. PD-1/PD-L1-IN-27 shows antitumor effects with low T cell cytotoxicity. PD-1/PD-L1-IN-27 has the ability to activate CD8+T cells and reduces T cell exhaustion[1].

IC50& Target

IC50: 134 nM (PD-1/PD-L1)[1]

体外研究
(In Vitro)

PD-1/PD-L1-IN-27 (compound MZ58) (2.5, 5, 10, 50 μM; 48 h) shows antitumor effects with low T cell cytotoxicity[1].

Cell Proliferation Assay[1]

Cell Line:MDA-MB-231 cells
Concentration:2.5, 5, 10, 50 μM
Incubation Time:48 h
Result:Facilitated cell proliferation with low T cell cytotoxicity.
体内研究
(In Vivo)

PD-1/PD-L1-IN-27 (10, 25 mg/kg; i.g.) shows antitumor effecct[1].

Animal Model:20-22 g, 6-8 weeks, male C57BL/6J mice (MC 38 cell lines)[1]
Dosage:10, 25 mg/kg
Administration:I.g.
Result:Showed antitumor effecct.
分子量

673.75

Formula

C44H35NO6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.