ASP1126

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ASP1126

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1228580-11-7

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

ASP1126 是选择性的、具有口服活性的鞘氨醇1-磷酸 (S1P)的激动剂，对 hS1P₁和 hS1P₃的EC₅₀值分别为 7.12 nM 和 517 nM。ASP1126可减少外周血淋巴细胞、初代T细胞、中央记忆T细胞和效应记忆T细胞的数量。ASP1126具有较好的安全性，具有应用于临床移植的潜力。

生物活性

ASP1126 is a selective and orally activesphingosine-1-phosphate (S1P)agonist, withEC₅₀values of 7.12 nM, 517 nM for hS1P₁and hS1P₃, respectively. ASP1126 decreases the number of peripheral lymphocytes, naive T cells, central memory T cells and effector memory T cells in the peripheral blood. ASP1126 has the potential to be applied in clinical transplantation with improved safety profile^[1].

IC₅₀& Target

EC50: 7.12 nM (hS1P₁), 517 nM (hS1P₃)^[1].

体内研究
(In Vivo)

ASP1126 (1 and 5 mg/kg, orally once daily for 14 days) significantly prolongs allograft survival^[1].
ASP1126 in combination with 0.02 mg/kg tacrolimus notably improves graft survival time^[1].

Animal Model:	ACI and Lewis rats aged 6 weeks were used as cardiac donors and recipients, respectively^[1].
Dosage:	0.2 mg/kg, 1 mg/kg, 5 mg/kg.
Administration:	Orally once daily for 14 days.
Result:	Significantly prolonged allograft survival (median survival time [MST] =9; 8 days at 1 and 5 mg/kg, respectively, compared with 6 days in the vehicle group).

分子量

581.93

Formula

C₂₆H₂₆ClF₆NO₅

CAS 号

1228580-11-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.