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Efalizumab
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:214745-43-4
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
Efalizumab 是一种靶向 T 细胞的调节剂,是 LFA-1 α 亚基CD11a的人源化单克隆抗体。依法珠单抗可抑制 T 细胞激活、皮肤T细胞运输和T细胞粘附到角质形成细胞,可用于斑块银屑病研究。
生物活性

Efalizumab is a targeted T cell modulator, and is a humanized monoclonal antibody ofCD11a, the α subunit of LFA-1. Efalizumab inhibits T cell activation, cutaneous T cell trafficking, and T cell adhesion to keratinocytes, can be used for plaque psoriasis research[1].

体外研究
(In Vitro)

Efalizumab (78 ng/mL-5 mg/mL) induces a leukocytosis and downregulates LFA-1 expression on T cells in the peripheral blood[3].
Efalizumab (78 ng/mL-5 mg/mL) downregulates plate-bound, anti-CD3-stimulated proliferation of PBMC[3].

体内研究
(In Vivo)

Efalizumab shows side effects include bacterial sepsis, viral meningitis, invasive fungal disease and progressive multifocal leukoencephalopathy (PML), a brain infection caused by reactivation of latent JC virus infection[2].

Clinical Trial
CAS 号

214745-43-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.