CD31 (PECAM-1) is platelet endothelial cell adhesion molecule-1, serves as theendothelial cell-specificreceptor of clostridium perfringens b-Toxin (CPB). CD31 is also anER-MP12 antigen, acts as a linker between mechanical stress, metabolism and inflammation. CD31 peptide is able to sustain phosphorylation of theCD31 ITIM₆₈₆and ofSHP2and to inhibitTCR-induced T-cell activation^[1]-[5].

CD31 is a trans-homophilic co-signaling protein at the crossroad between mechanical stress, metabolism and inflammation^[1].
CD31 is a ER-MP12 antigen, exerts function as promoting cell adhesion between endothelial cells, enabling transmigration of leukocytes across vascular endothelium, and producing signaling to up-regulation of other adhesion molecules in neighboring cells^[2].
Clostridium perfringens b-toxin (CPB) is a highly active b-pore-forming toxin (b-PFT) and the essential virulence factor for fatal, necro-hemorrhagic enteritis^[3].
CD31 serves as the specific membrane receptor for clostridium perfringens b-toxin (CPB) on endothelial cells. CD31 directly interacts with CPB, with the membrane proximal Ig6 domain^[3].
CD31 also serves as a therapeutic target in atherosclerosis^[4].
CD31 (0, 25, 50, 100 μg/mL) induces proliferative response to TCR engagement of human PBMCs in a dose-dependent manner^[5].

2601.10

C₁₁₉H₂₀₂N₃₆O₂₉

161374-99-8

NHASSVPRSKILTVRVILAPWKK

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.