CAS NO: | 2245725-04-4 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
生物活性 | Tebotelimab (MGD-013) is a human IgG4κ bispecificPD-1/LAG-3dual-affinity re-targeting (DART) antibody. Tebotelimab binds cell-surface expressedPD-1andLAG-3with EC50s of 1.65 nM and 0.41 nM in NS0 cells, respectively. Tebotelimab blocksPD-1/PD-L1, PD-1/PD-L2 and LAG-3/HLA (MHC-II) interactions andPD-1signaling. Tebotelimab restores exhausted T-cell responses and and enhances antitumour immunity[1][2][3]. |
体外研究 (In Vitro) | MGD013 (0.39, 1.56, 6.25, 25 nM; 48 小时) 增强人 PBMC 中 T 细胞抗原受体驱动的激活。与 PD-1 + LAG-3 mAb 组合相比,MGD013 显示增强的葡萄球菌肠毒素 B (SEB; 0.5mg/mL) 诱导 IFN-γ 分泌[1]。 |
CAS 号 | 2245725-04-4 |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |