Peldesine (BCX 34) dihydrochloride is a potent, competitive, reversible and orally activepurine nucleoside phosphorylase (PNP)inhibitor withIC₅₀s of 36 nM, 5 nM, and 32 nM forhuman, rat, and mouse red blood cell (RBC) PNP, respectively. Peldesine dihydrochloride is also aT-cellproliferation inhibitor with anIC₅₀of 800 nM. Peldesine dihydrochloride has the potential for cutaneous T-cell lymphoma, psoriasis andHIVinfectionresearch^[1][2][3][4].

IC50: 36 nM (Human RBC PNP), 5 nM (Rat RBC PNP), 32 nM (Mouse RBC PNP), and 800 nM (Human T-cell proliferation)^[3]
Ki: 23 nM (Human RBC PNP)^[3]
HIV^[4]

Peldesine (BCX 34; 0-50 μM; 72 hours; Jurkat cells) could inhibit the T-cell proliferation completely at a concentration of less than 10 μM, in the presence of dGuo (10 μM). In contrast, the B-cell proliferation is not affected by Peldesine^[1].
Peldesine (BCX 34) suppresses T-cell immune reaction in an IL-2-independent manner, and this means that Peldesine might affect a late phase rather than an early stage in T-cell activation^[1].
Peldesine also, in the presence but not in the absence of deoxyguanosine, inhibits human leukemia CCRF-CEM T-cell proliferation with an IC₅₀of 0.57 μM but not rat or mouse T-cell proliferation up to 30 μM^[3].

314.17

Solid

C₁₂H₁₃Cl₂N₅O

2772702-10-8

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

DMSO : 200 mg/mL(636.60 mM;Need ultrasonic)

H₂O : 33.33 mg/mL(106.09 mM;Need ultrasonic)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。