| CAS NO: | 4991-65-5 |
| 包装: | 50mg |
| 市场价: | 483元 |
| Cas No. | 4991-65-5 |
| 别名 | 噻克索酮 |
| 化学名 | 6-hydroxybenzo[d][1,3]oxathiol-2-one |
| Canonical SMILES | OC1=CC(OC(S2)=O)=C2C=C1 |
| 分子式 | C7H4O3S |
| 分子量 | 168.17 |
| 溶解度 | ≥ 63.2 mg/mL in DMSO, ≥ 22.7 mg/mL in EtOH with ultrasonic, ≥ 2.33 mg/mL in Water with ultrasonic and warming |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Tioxolone, a metalloenzyme carbonic anhydrase I inhibitor, is an anti-acne preparation.Target: Carbonic Anhydrase Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor with a Ki of 91 nM. Tioxolone lacks sulfonamide, sulfamate, or hydroxamate functional groups that are typically found in therapeutic carbonic anhydrase (CA) inhibitors, such as acetazolamide. Tioxolone is proposed to be a prodrug inhibitor that is cleaved via a CA II zinc-hydroxide mechanism known to catalyze the hydrolysis of esters. When tioxolone binds in the active site of CA II, it is cleaved and forms 4-mercaptobenzene-1,3-diol via the intermediate S-(2,4-thiophenyl) hydrogen thiocarbonate. The esterase cleavage product binds to the zinc active site via the thiol group and is therefore the active CA inhibitor, while the intermediate is located at the rim of the active-site cavity. From Wikipedia. References: |
m.cnreagent.com