| CAS NO: | 554-57-4 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 50mg | 电议 |
| Cas No. | 554-57-4 |
| 别名 | 醋甲唑胺; L584601 |
| 化学名 | N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)acetamide |
| Canonical SMILES | CC(=O)N=C1N(N=C(S1)S(=O)(=O)N)C |
| 分子式 | C5H8N4O3S2 |
| 分子量 | 236.27 |
| 溶解度 | ≥ 7.25 mg/mL in DMSO, ≥ 11.18 mg/mL in EtOH with ultrasonic and warming, ≥ 2.58 mg/mL in Water with ultrasonic and warming |
| 储存条件 | Store at -20℃,protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Methazolamide, a derivative of sulfonamide, is an inhibitor of carbonic anhydrase (CA) that potently inhibits isoenzymes of CA, CA II and CA IV with values of 50% inhibition concentration IC50 of 8.1 nM and 80.3 nM respectively. Methazolamide has been widely used to treat glaucoma for its ability to reduce the rate of fluid formation in the inner eye through slowing the formation of bicarbonate ions and subsequently resulting in reduction in sodium and fluid transport. Recent studies have revealed that methazolamide, while other CA inhibitos are not, also acts as an insulin sensitizer to suppress hepatic glucose production in vivo. Reference [1].Konstantopoulos N, Molero JC, McGee SL, Spolding B, Connor T, de Vries M, Wanyonyi S, Fahey R, Morrison S, Swinton C, Jones S, Cooper A, Garcia-Guerra L, Foletta VC, Krippner G, Andrikopoulos S, Walder KR. Methazolamide is a new hepatic insulin sensitizer that lowers blood glucose in vivo. Diabetes. 2012;61(8):2146-2154 |
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