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Masavibart
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:2640223-84-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
ZRC3308-A7
产品介绍
Masavibart (ZRC3308-A7) 是一种靶向SARS-CoV-2的单克隆抗体 (IgG1 型)。Masavibart 对SARS-CoV-2穗状蛋白的RBD上的非竞争性表位显示出良好的结合亲和力。Masavibart 可按 1:1 与 ZRC3308-B10 (HY-145643) 联合使用,对 COVID-19 的预防以及尚未发展为严重疾病的早期 COVID-19 有效。
生物活性

Masavibart (ZRC3308-A7) is ananti-SARS-CoV-2 monoclonal antibody(IgG1 type). Masavibart shows good binding affinity to a non-competing epitope on theRBDof theSARS-CoV-2spike protein. Masavibart can be used in combination withZRC3308-B10(HY-145643) at a ratio of 1:1, which is effective for the prevention of COVID-19 and the early stage of COVID-19 before the development of severe disease[1].

IC50& Target

SARS-CoV-2[1].

体外研究
(In Vitro)

Masavibart (ZRC3308-A7; 0-5×105ng/mL) shows virus neutralizing ability in VeroE6/Vero CCL81 (SARS-CoV-2 infection model) cells, when in combination with ZRC3308-B10 (ratio 1:1)[1].
Masavibart neutralizes SARS-CoV-2 variants B.1.1.7, B.1.351, B.1.617.2, and B.1.617.2 AY.1 in vitro, when in combination with ZRC3308-B10 (ratio 1:1)[1].
Masavibart binds to the RBD of SARS-CoV-2 S1 protein[1].

Cell Viability Assay[1]

Cell Line:VeroE6/Vero CCL81 cells (SARS-CoV-2 infection model)
Concentration:0-5×105ng/mL (in combination with ZRC3308-B10)
Incubation Time:72 h
Result:Showed potent neutralization activity with an IC50of 0.1527 ng/mL.
体内研究
(In Vivo)

Masavibart (ZRC3308-A7; 0.5, 2.5, 25 mg/kg; 48 h prior to the SARS-CoV-2 infection) effectively prevents SARS-CoV-2 infection in syrian hamster, when in combination with ZRC3308-B10 (ratio 1:1)[1].
Masavibart (0.5, 2.5, 25 mg/kg; i.p.; single) shows the serum levels remaines constant without much reduction for up to 7 days, in syrian hamster[1].

Animal Model:Female syrian hamster (7 to 10-week-old; SARS-CoV-2 infection model)[1].
Dosage:0.5, 2.5, 25 mg/kg
Administration:Intraperitoneal injection; 48 h prior to the SARS-CoV-2 infection
Result:Prevented SARS-CoV-2 infection when in combination with ZRC3308-B10.
CAS 号

2640223-84-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.