Ogalvibart

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Ogalvibart

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2599039-60-6

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议

产品名称

C-135-LS
BMS-986414

产品介绍

Ogalvibart (C-135-LS) 是一种人源化抗 SARS-CoV-2 单克隆抗体(IgG1 型)。Ogalvibart 可与SARS-CoV-2的刺突 (S) 糖蛋白受体结合域(RBD) 结合。Ogalvibart 联合 C144LS 使用 (比例为 1:1) 具有良好的预防活性，能有效地阻断恒河猴疾病模型中 COVID19 的发展。

生物活性

Ogalvibart (C-135-LS) is ahumanized anti-SARS-CoV-2 monoclonal antibody(IgG1 type). Ogalvibart binds to thespike (S)glycoproteinreceptor-binding domain (RBD)ofSARS-CoV-2. Ogalvibart in combination with C144LS (1:1 ratio) shows good preventive activity and can effectively block the development of COVID19 in a rhesus monkey disease model^[1].

IC₅₀& Target

SARS-CoV-2^[1].

体内研究
(In Vivo)

Ogalvibart (C-135-LS; 10 mg/kg; 75 days before infection) in combination with 10 mg/kg C144LS can effectively block development of COVID-19 in the rhesus disease model^[1].

Animal Model:	Rhesus macaques (3-11 years old)^[1].
Dosage:	10 mg/kg (in combination with 10 mg/kg C144LS)
Administration:	75 days before infection
Result:	Protected a subset of animals whose infectious challenge was 75 days post administration from disease.

CAS 号

2599039-60-6

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.