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Garivulimab
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:2342597-81-1
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品名称
BGB-A333
产品介绍
Garivulimab (BGB-A333) 是一种人源化 IgG1 变体单克隆抗体,可特异性靶向并结合PD-L1。Garivulimab 选择性地阻断 PD-L1 和 PD-1 的相互作用,具有抗肿瘤活性。
生物活性

Garivulimab (BGB-A333) is a humanized IgG1-variant monoclonal antibody that specifically targets and binds toPD-L1. Garivulimab selectively blocks the interaction ofPD-L1andPD-1. Garivulimab has antitumor activity[1].

体外研究
(In Vitro)

Garivulimab (BGB-A333) specifically targets and binds to PD-L1, blocking interaction to its receptor, PD-1 on T cell, reversing T cell inactivation, and increases T cell expansion resulting in cytotoxic T cell-mediated antitumor immune response against PD-L1-expressing tumor cells. Garivulimab also inhibits PD-L1-induced apoptosis of activated CD8+ T cells and increases T cell proliferation[1].

CAS 号

2342597-81-1

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.