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BML-280
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BML-280图片
CAS NO:1158347-73-9
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
VU0285655-1
产品介绍
BML-280 (VU0285655-1) 是一种有效的选择性磷脂酶 D2 (PLD2) 抑制剂。BML-280 能够防止高糖诱导的 caspase-3 裂解和细胞活力降低。BML-280 可用于类风湿关节炎的研究。
生物活性

BML-280 (VU0285655-1) is a potent and selectivephospholipaseD2 (PLD2)inhibitor. BML-280 has the ability to prevent caspase-3 cleavage and reduction in cell viability induced by high glucose. BML-280 can be used for rheumatoid arthritis research[1][2].

IC50& Target

PLD2

 

PLD1

 

IL-1β

 

IL-8

 

体外研究
(In Vitro)

BML-280 shows an approximately 21-fold selectivity for PLD2[3].
BML-280 (0-0.1 μM) suppresses formyl-Met-Leu-Phe (fMLP)-stimulated PLD activity in a concentration dependent manner, with an IC50of 0.04 ± 0.01 μM[3].
BML-280 (0-0.3 μM) inhibits O2- generation, and the inhibition reaches a plateau (about 20 % inhibition) at around 0.01 μM to 0.3 μM[3].
BML-280 (0-5 μM, 24 h) reduces proliferation in PLD1-deficient cells, but also in PLD2-deficient cells exposed to IGF-1 (Insulin-like growth factor 1)[1].
BML-280 inhibits mRNA levels and secretion of tumor necrosis factor-α, IL-1β and IL-8 in human periodontal ligament cells[2].

Cell Proliferation Assay[1]

Cell Line:Wild-type, PLD1- and PLD2-deficient astrocytes
Concentration:0, 50, 500, and 5000 nM
Incubation Time:24 h
Result:Had minor effects in wild-type and PLD2-deficient cells, but completely blocked PLD activity in PLD1-deficient cells. Caused a highly significant inhibition of glial proliferation when astrocytes were stimulated by FCS (fetal calf serum) or IGF-1, respectively. Showed non-specific effects because they inhibited cell proliferation even in PLD1/2 double knockouts at 5 μM.
分子量

429.51

Formula

C25H27N5O2

CAS 号

1158347-73-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.