CAS NO: | 5959-95-5 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | D-Glutamine is a cell-permeable D type stereoisomer of Glutamine. | ||||||||||||||||
IC50& Target |
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体外研究 (In Vitro) | Glutamine is a key amino acid in the central nervous system (CNS), playing an important role in the glutamate/GABA-Glutamine cycle (GGC). In the GGC,Glutamine is transferred from astrocytes to neurons, where it will replenish the inhibitory and excitatory neurotransmitter pools[1]. D-Glutamine has been used to study its role in conferring protection against acetaldehyde-induced disruption of barrier function in Caco-2 cell monolayer. Role of L-Glutamine in the protection of intestinal epithelium from acetaldehyde-induced disruption of barrier function is evaluated in Caco-2 cell monolayer. L-Glutamine reduced the acetaldehyde-induced decrease in transepithelilal electrical resistance and increase in permeability to inulin and lipopolysaccharide in a time- and dose-dependent manner; D-Glutamine, L-aspargine, L-arginine, L-lysine, or L-alanine produced no significant protection. D-Glutamine also fails to influence the acetaldehyde-induced decrease in TER and increase in inulin flux. D-Glutamine or glutaminase inhibitor by themselves did not influence TER or inulin flux in control or acetaldehyde-treated cell monolayers. Lack of effect of D-Glutamine in protection from acetaldehyde indicates that the L-Glutamine-mediated protection is stereospecific[2]. | ||||||||||||||||
分子量 | 146.14 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C5H10N2O3 | ||||||||||||||||
CAS 号 | 5959-95-5 | ||||||||||||||||
中文名称 | D-谷氨酰胺 | ||||||||||||||||
结构分类 |
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: H2O : 20 mg/mL(136.86 mM;ultrasonic and adjust pH to 2 with HCl) DMSO : 4 mg/mL(27.37 mM;ultrasonic and warming and adjust pH to 5 with HCl and heat to 60℃) 配制储备液
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