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Pristinamycin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pristinamycin图片
CAS NO:270076-60-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
200mg电议

产品名称
Pristinamycine
产品介绍
Pristinamycin 是一种具有口服活性的链霉素样的抗生素,产生于Streptomyces pristinaespiralis,Pristinamycin 由两种化学上不相关的成分组成:Pristinamycin I (PI) 和 Pristinamycin II (PII)。Pristinamycin 对多种抗生素耐药病原菌,特别是革兰氏阳性菌,包括耐甲氧西林金黄色葡萄球菌 (MRSA)、万古霉素耐药金黄色葡萄球菌 (VRSA) 和粪肠球菌 (VREF) 具有高度的活性。
生物活性

Pristinamycin, produced byStreptomyces pristinaespiralis, is an orally active streptogramin-likeantibioticconsisting of two chemically unrelated components: Pristinamycin I (PI) and Pristinamycin II (PII). Pristinamycin is highly active against many antibiotic-resistant pathogens, particularly Gram-positive bacteria, including Methicillin-resistantStaphylococcus aureus(MRSA), Vancomycin-resistantS. aureus(VRSA) andEnterococcus faecium(VREF)[1].

体外研究
(In Vitro)

In-vitro studies show pristinamycin to inhibitStaphylococciandStreptococci, including Erythromycin highly-resistant organisms, at a concentration of less than or equal to 0.78 mg/l[2].

体内研究
(In Vivo)

To study Pristinamycin activity in vivo, mice infected IP with C. psittaci. Mortality in the control group was 70%. Three groups of mice received 25 mg/kg, 50 mg/kg and 100 mg/kg Pristinamycin respectively. The antibiotic was active in the 100 mg/kg dosage which is the therapeutic dosage[3].

Clinical Trial
分子量

1392.55

性状

Solid

Formula

C73H89N11O17

CAS 号

270076-60-3

结构分类
  • Antibiotics
  • Macrolide Antibiotics
来源

streptogramin

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
In solvent-80°C6 months
-20°C1 month