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(-)-Cleistenolide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(-)-Cleistenolide图片
CAS NO:1003600-48-3
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
Cleistenolide
产品介绍
(-)-Cleistenolide 是一种 α,β- 不饱和 δ- 内酯,从Cleistochlamys kirkiiOliver 中分离得到。(-)-Cleistenolide 具有抗菌和抗肿瘤活性。
生物活性

(-)-Cleistenolide is a α,β-unsaturated δ-lactone isolated fromCleistochlamys kirkiiOliver. (-)-Cleistenolide has antibacterial and antitumor activity[1].

体外研究
(In Vitro)

(-)-Cleistenolide (compound 1) exhibits potent cytotoxicity against cancer cell lines and low cytotoxicity in normal cells MRC-5[1].

Cell Cytotoxicity Assay

Cell Line:K562, HL-60, Jurkat, Raji, MCF-7, MDA-MB 231, HeLa, A549 and MRC-5[1]
Concentration:0-100 μM
Incubation Time:
Result:Exhibited potent cytotoxicity against cancer cell lines with IC50s of 7.65 μM, 1.21 μM, 14.22 μM, 36.94 μM, 26.07 μM, 2.25 μM, 7.32 μM and 16.34 μM in K562, HL-60, Jurkat, Raji, MCF-7, MDA-MB 231, HeLa and A549, respectively; and had low cytotoxicity in normal cells MRC-5 with an IC50over 100 μM.
分子量

362.33

Formula

C18H18O8

CAS 号

1003600-48-3

结构分类
  • Antibiotics
  • Beta-lactam Antibiotics
来源
  • Plants
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.