Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid)，Lithocholic acid (HY-10219) 的衍生物，是一种 T 细胞调节剂。Isoallolithocholic acid 增强调节性 T 细胞 (Tregs) 的分化。
| 生物活性 | Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid), a derivative ofLithocholic acid(HY-10219), is a T cell regulator. Isoallolithocholic acid enhances regulatory T cells (Tregs) differentiation[1]. |
体外研究
(In Vitro) | Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid) (20 μM) reduces Th17 cell differentiation by ~50% without affecting RORγt expression[1].
Isoallolithocholic acid does not affect T cell differentiation into Th1 or Th2 cells, the modulatory effect of Isoallolithocholic acid on Tregs is cell-type specific[1].
Isoallolithocholic acid-dependent enhanced expression of FoxP3 requires mitoROS[1].
|
体内研究
(In Vivo) | Isoallolithocholic acid (0.03%; in diet; 7 days) enhances Treg cells in B6 mice[1].
| Animal Model: | Segmented filamentous bacteria (SFB)-colonized Jax-B6 mice[1] | | Dosage: | 0.03% (w/w) | | Administration: | In diet, 7 days | | Result: | Was insufficient to enhance Treg percentages both at steady state and following anti-CD3 treatment alone. Significantly enhanced the Treg population in mice treated with anti-CD3 compared to control diet in combination with 0.3% (w/w) 3-oxolithocholic acid (3-oxoLCA). Reduced the number of CD45.1+T effector cells. |
|
| 分子量 | |
| 性状 | |
| Formula | |
| CAS 号 | |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | | Powder | -20°C | 3 years | | 4°C | 2 years | | In solvent | -80°C | 6 months | | -20°C | 1 month |
|
| 溶解性数据 | In Vitro: DMSO : 83.33 mg/mL(221.29 mM;ultrasonic and warming and heat to 60℃) 配制储备液 | 1 mM | 2.6555 mL | 13.2777 mL | 26.5555 mL | | 5 mM | 0.5311 mL | 2.6555 mL | 5.3111 mL | | 10 mM | 0.2656 mL | 1.3278 mL | 2.6555 mL |
*请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。 |
m.cnreagent.com