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Malvidin-3-O-arabinoside chloride
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Malvidin-3-O-arabinoside chloride图片
CAS NO:28500-04-1
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
Malvidin-3-O-arabinoside chloride 通过刺激 Ampk 介导的自噬(autophagy)，改善氨基甲酸乙酯诱导的氧化损伤。
生物活性

Malvidin-3-O-arabinoside chloride ameliorates ethyl carbamate-induced oxidative damage by stimulating AMPK-mediatedautophagy[1].

体外研究
(In Vitro)

Malvidin-3-O-arabinoside chloride (M3A chloride, 50-400 μM) pretreatment remarkably upregulates LAMP-1 expression, which indicates elevated lysosomal mass. M3A also successfully restores lysosomal acidity and subsequently strengthenes lysosomal functions. M3A stimulates phosphorylation of AMP-activated protein kinase (AMPK), a master regulator of autophagy[1].

Cell Autophagy Assay[1]

Cell Line:Caco-2 cell line.
Concentration:50, 100, 200 and 400 μM.
Incubation Time:24 h (then treated with or without 10 μM chloroquine (CQ) for another 1 h).
Result:Notably inhibited excess ROS generation.
200 μM and 400 μM M3A pretreatment significantly enhanced 14% and 16% of GSH level.
Enhanced autophagy flux.
Significantly up-regulate the LC3-II/LC3-I ratio.
分子量

498.86

Formula

C22H23ClO11

CAS 号

28500-04-1

结构分类
  • Flavonoids
  • Anthocyans
  • Phenols
  • Polyphenols
来源
  • Plants
  • Ericaceae
  • Vaccinium myrtillusLinn.
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.