Zardaverine 是一种新开发的双选择性 PDE3/4 抑制剂，IC50 值分别为 0.5 uM 和 0.8 uM。
| Cas No. | 101975-10-4 |
| 别名 | 扎达维林 |
| 化学名 | 6-(4-(difluoromethoxy)-3-methoxyphenyl)pyridazin-3(2H)-one |
| Canonical SMILES | COC1=C(OC(F)F)C=CC(C2=NNC(C=C2)=O)=C1 |
| 分子式 | C12H10F2N2O3 |
| 分子量 | 268.22 |
| 溶解度 | DMSO: 100mM |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Zardaverine is a newly developed dual-selective phosphodiesterase (PDE) III and IV inhibitor. Zardaverine inhibited the cyclic GMP-inhibitable PDE III from human platelets and the rolipram-inhibitable PDE IV from canine trachea and human polymorphonuclear (PMN) cells with IC50-values of 0.58, 0.79 and 0.17 μM, respectively. The pyridazinone derivative affected the calmodulin-stimulated PDE I, the cyclic GMP-stimulated PDE II and the cyclic GMP-specific PDE V only marginally at concentrations up to 100μM. Zardaverine inhibits the ADP-induced aggregation of human platelets with an IC50 of 1.6 μM. This inhibition was synergistically increased by activators of adenylate cyclase such as PGE1 and forskolin. In human PMN cells, Zardaverine inhibited the zymosan-induced superoxide anion generation with an IC50 of 0.40 μM. Again, this effect was increased by activators of adenylate cyclase. Zardaverine acted in synergy with the adenylate cyclase activators prostaglandin E2 and CG 4203, a prostacyclin analog, and super-additive effects of combinations were observed. Zardaverine and dexamethasone prevent bronchial eosinophilia and neutrophilia with similar dosage of 30 microM/kg orally, suggesting that this PDE III/IV inhibitor may be useful for both, bronchorelaxation and reduction of inflammation in asthma therapy. |
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