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Pilocarpine nitrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pilocarpine nitrate图片
CAS NO:148-72-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
硝酸毛果芸香碱
产品介绍
Pilocarpine nitrate 是一种有效的 M3 型毒蕈碱乙酰胆碱受体 (M3 muscarinic receptor) 激动剂。
生物活性

Pilocarpine nitrate is a potent M3-typemuscarinic acetylcholine receptor(M3 muscarinic receptor) agonist.

IC50& Target

M3 muscarinic receptor[1]

体外研究
(In Vitro)

To evaluate the cytotoxicity of Pilocarpine, the morphology and viability of human corneal stromal (HCS) cells are examined by light microscopy and MTT assay, respectively. Morphological observations show that HCS cells exposed to Pilocarpine at a concentration from 0.625 to 20 g/L exhibit dose- and time-dependent proliferation retardation and morphological abnormality such as cellular shrinkage, cytoplasmic vacuolation, detachment from culture matrix, and eventually death, while no obvious difference is observed between those exposed to Pilocarpine below the concentration of 0.625 g/L and controls. Results of MTT assay reveal that the cell viability of HCS cells decrease with time and concentration after exposing to Pilocarpine above the concentration of 0.625 g/L (P<0.01 or 0.05), while that of HCS cells treated with Pilocarpine below the concentration of 0.625 g/L show no significant difference to controls[2]. The partial muscarinic agonist, Pilocarpine, evokes concentration-dependent relaxation with an EC50of 2.4 mM in isolated segments of rat tail artery that were constricted with Penylephrine (10 to 200 nM)[3].

体内研究
(In Vivo)

The Pilocarpine-induced saliva secretion of the control rats (CN) and exercised (EX) rats is examined. A significantly greater amount of saliva is induced by Pilocarpine in the EX rats than in the CN rats (P<0.01). Conversely, the Na+concentration in the saliva of the EX rats is significantly lower than that of the CN rats (P<0.05)[1].

Clinical Trial
分子量

271.27

Formula

C11H17N3O5

CAS 号

148-72-1

中文名称

匹鲁卡品硝酸盐;硝酸毛果芸香碱

结构分类
  • Alkaloids
  • Other Alkaloids
来源
  • Plants
  • other families
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.