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Topotecan
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Topotecan图片
CAS NO:123948-87-8
包装与价格:
包装价格(元)
10mg电议
50mg电议
100mg电议

产品名称
拓扑替康
SKF 104864A
NSC 609669
产品介绍
Topotecan (SKF 104864; NSC 609669) 是一种口服有效的拓扑异构酶 I (Topoisomerase I) 抑制剂。Topotecan 诱导细胞周期阻滞在 G0/G1 和 S 期,促进凋亡 (apoptosis)。Topotecan 具有抗癌活性。
生物活性

Topotecan (SKF 104864A; NSC 609669) is an orally active and potentTopoisomeraseIinhibitor. Topotecan induces cell cycle arrest in G0/G1 and S phases and promotesapoptosis. Topotecan shows anticancer activity[1].

IC50& Target[1]

Topoisomerase I

 

体外研究
(In Vitro)

Topotecan obviously inhibits proliferation of human glioma cells and glioma stem cells (GSCs) in a dose- and time-dependent manner[1].
Topotecan (0-40 μM) obviously inhibits the cell viability compared with the control groups, in a dose-dependent manner[1].
Topotecan shows anti-proliferation activity against U251, U87, GSCs-U251 and GSCs-U87 cells, withIC50values of 2.73±0.25, 2.95±0.23, 5.46±0.41, and 5.95±0.24 μM, respectively[1].

体内研究
(In Vivo)

NUB-7 metastatic model, the animals belonging to all the 4 groups are sacrificed after 14 days treatment. Compared with the control, Low dose metronomic (LDM) Topotecan (TP) and TP+Pazopanib (PZ) liver weights are significantly lower in TP+PZ-treated animals, compared with PZ. Microscopic tumors are visible in the livers of mice belonging to all the groups except TP+PZ confirming the ability of TP+PZ to control liver metastasis[2].
Topotecan (0.5, 1.0, and 1.5 mg/kg; Orally, daily) causes greater reduction in microvascular density in an ovarian cancer model, but the mice treated with 1.5 mg/kg daily, oral Topotecan show decreased food intake, and a lesser antitumor effect[2].

Clinical Trial
分子量

421.45

Formula

C23H23N3O5

CAS 号

123948-87-8

中文名称

托泊替康;拓扑替康

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.