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Olutasidenib(FT-2102)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Olutasidenib(FT-2102)图片
CAS NO:1887014-12-1
包装与价格:
包装价格(元)
250mg电议
500mg电议

产品介绍
Olutasidenib (FT-2102) (FT-2102) 是一种高效、具有口服活性、脑渗透性和选择性的突变异柠檬酸脱氢酶 1 (IDH1) 抑制剂,对 IDH1- R132H 和 IDH1- R132C 的 IC50 值为 21.2 nM 和 114 nM , 分别 。
Cas No.1887014-12-1
别名FT-2102
Canonical SMILESN#CC1=CC=C(N[C@H](C2=CC3=C(NC2=O)C=CC(Cl)=C3)C)C(N1C)=O
分子式C18H15ClN4O2
分子量354.79
溶解度DMSO: 125 mg/mL (352.32 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Olutasidenib is a highly potent, selective inhibitor of mutant Isocitrate dehydrogenase (IDH)1 that could be used in the treatment of acute myeloid leukemia.

[1]. JM Watts, et al. A phase 1 dose escalation study of the IDH1m inhibitor, FT-2102, in patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).