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Inarigivir ammonium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Inarigivir ammonium图片
CAS NO:2172788-92-8
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议

产品名称
ORI-9020 ammonium
SB-9000 ammonium
产品介绍
Inarigivir (ORI-9020) ammonium 是一种二核苷酸抗病毒化合物,可显着减少表达乙型肝炎病毒转基因小鼠的HBVDNA。Inarigivir (ORI-9020) 是维甲酸诱导基因-I(RIG-I)的激动剂,可激活细胞内的先天免疫。
生物活性

Inarigivir (ORI-9020) ammonium is a dinucleotide antiviral drug that can significantly reduce liverHBVDNA in transgenic mice expressing hepatitis B virus. Inarigivir (ORI-9020) ammonium acts as aRIG-I (Retinoic acid-inducible gene-I)agonist to activate cellular innate immune responses[1][2].

IC50& Target

Target: HBV[1].

体外研究
(In Vitro)

Inarigivir (SB 9200) is active against HBV variants carrying resistance markers against all the nucleos(t)ide analogues approved for treating chronic hepatitis B[2].

体内研究
(In Vivo)

Inarigivir (100 mg/kg/day, ip) significantly reduces viral DNA in the liver and shows anti-HBV activity. Serum HBV DNA is not reduced in response to treatment. Inarigivir does not affect levels of HBV RNA in liver, levels of HBeAg in serum, or mean titers of HBsAg. The minimal effective dose is identified to be between 1.6 and 0.5 mg/kg/day using liver HBV DNA values[1].

Animal Model:Mice[1]
Dosage:100 mg/kg.
Administration:IP, daily.
Result:Significantly reduced viral DNA in the liver and shows anti-HBV activity similar ADV positive control.
Clinical Trial
分子量

604.53

性状

Solid

Formula

C20H29N8O10PS

CAS 号

2172788-92-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O : 100 mg/mL(165.42 mM;Need ultrasonic)

DMSO : 100 mg/mL(165.42 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM1.6542 mL8.2709 mL16.5418 mL
5 mM0.3308 mL1.6542 mL3.3084 mL
10 mM0.1654 mL0.8271 mL1.6542 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: PBS

    Solubility: 100 mg/mL (165.42 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在本网站选购。