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Rebaudioside A
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Rebaudioside A图片
CAS NO:58543-16-1
包装:20mg
市场价:1880元

产品介绍
Rebaudioside A 是一种甜菊醇糖苷，α-葡萄糖苷酶抑制剂，IC50 为 35.01 μg/ml。
Cas No.58543-16-1
别名莱苞迪甙 A
化学名Rebiana; Stevioside a3; Sweetener 4G-S
Canonical SMILESO[C@@H]1[C@@H](CO)O[C@@]([H])(OC2C[C@]([C@@](CCC[C@@]3(C)C(OC4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)=O)(C)[C@]3([H])CC5)([H])C5(C6)CC2C6=C)[C@H](O[C@@]7([H])[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O7)C1O[C@@]8([H])[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O8
分子式C44H70O23
分子量967.1
溶解度DMF: 1 mg/ml,DMSO: 1 mg/ml,PBS (pH 7.2): 10 mg/ml
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Rebaudioside A is a steviol glycoside, α-glucosidase inhibitor with IC50 of 35.01 μg/ml.can inhibit ATP-sensitive K+-channels.Target: α-glucosidase [1]IC 50: 35.01 ug/mLIn vitro: rebaudioside A stimulat the insulin secretion from MIN6 cells in a dose- and glucose-dependent manner. In conclusion, the insulinotropic effect of rebaudioside A is mediated via inhibition of ATP-sensitive K+-channels and requires the presence of high glucose. [2]In vivo: in vivo mouse micronucleus test at doses up to 750 mg/kg bw and an unscheduled DNA synthesis test in rats at doses up to 2000 mg/kg bw, rebaudioside A do not cause any genotoxic effects at any of the doses tested.[3]

References:
[1]. Adari BR et al. Synthesis of rebaudioside-A by enzymatic transglycosylation of stevioside present in the leaves of Stevia rebaudiana Bertoni. Food Chem. 2016 Jun 1;200:154-8.
[2]. Abudula R et al. Rebaudioside A directly stimulates insulin secretion from pancreatic beta cells: a glucose-dependent action via inhibition of ATP-sensitive K-channels. Diabetes Obes Metab. 2008 Nov;10(11):1074-85.
[3]. Williams LD et al. Genotoxicity studies on a high-purity rebaudioside A preparation. Food Chem Toxicol. 2009 Aug;47(8):1831-6.