CS1 is a potentDNATopo IIαinhibitor. CS1 displays broad-spectrum in vitro antitumor effects, low toxicity in vivo and potential anti-multidrug resistance capabilities. CS1 leads to DNA damage, cell cycle arrest at G2/M phase andapoptosis^[1].

CS1 shows cytotoxicity withIC₅₀values of 16.92 and 18.88 μM for MCF-7 and MCF7/ADR cells, respectively^[1]
. CS1 (10, 50, 100 μM) inhibits the activity of topoisomerase II α (Topo IIα)^[1].
CS1 (0-20 μM) shows antiproliferation activity in cancer cells^[1].
CS1 (2.5, 5, 10 μM) induces cell cycle arrest at the G2/M phase^[1].
CS1 (2.5, 5, 10 μM) induces cell apoptosis^[1].
CS1 (5, 10, 15 μM; 24 h) induces DNA breaks in MDA-MB-231 cells^[1].

CS1 (20 mg/kg; i.v.; every other day for two weeks) shows antitumor effects^[1].

252.26

C₁₆H₁₂O₃

1448009-94-6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.