EGFR-IN-70

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EGFR-IN-70

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
5mg	电议
10mg	电议

产品介绍

EGFR-IN-70 (compound 18j) 是一种有效的EGFR抑制剂，对于 EGFR^LR/TM/CS和 EGFR^WT，其IC₅₀值分别为 23.6 和 307.5 nM。EGFR-IN-70 具有抗增殖活性并抑制 EGFR 的磷酸化。EGFR-IN-70 可用于癌症研究。

生物活性

EGFR-IN-70 (compound 18j) is a potentEGFRinhibitor withIC₅₀values of 23.6 and 307.5 nM forEGFR^LR/TM/CSandEGFR^WT, respectively. EGFR-IN-70 has anti-proliferative activity and suppresses phosphorylation of theEGFR. EGFR-IN-70 can be used forcancerresearch^[1].

IC₅₀& Target

IC₅₀: 23.6 nM (EGFR^LR/TM/CS) and 307.5 nM EGFR^WT)^[1]

体外研究
(In Vitro)

EGFR-IN-70 (compound 18j) (72 hours) has anti-proliferative activity and suppresses the proliferation of Ba/F3-EGFR^19del/TM/CS, PC-9-OR-EGFR^19del/TM/CSand A431- EGFR^WTcells with IC₅₀values of 0.052, 0.644 and 2.003 μM, respectively^[1].
EGFR-IN-70 (compound 18j) (0-1000 nM; 2 hours; Ba/F3-EGFR^19del/TM/CSand PC-9-OR-EGFR^19del/TM/CScells) can suppresse phosphorylation of the EGFR^[1].

Western Blot Analysis^[1]

Cell Line:	Ba/F3-EGFR^19del/TM/CSand PC-9-OR-EGFR^19del/TM/CScells
Concentration:	1, 3, 10, 30, 100, 300 and 1000 nM
Incubation Time:	2 hours
Result:	Suppressed phosphorylation of the EGFR and the downstream signaling ERK level.

分子量

626.17

性状

Solid

Formula

C₃₁H₃₆ClN₅O₅S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 100 mg/mL(159.70 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.5970 mL	7.9851 mL	15.9701 mL
5 mM	0.3194 mL	1.5970 mL	3.1940 mL
10 mM	0.1597 mL	0.7985 mL	1.5970 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。