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C3a(70-77)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
C3a(70-77)图片
CAS NO:63555-63-5
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
Complement 3a (70-77)
产品介绍
C3a (70-77) 是对应于C3a的COOH末端的八肽,表现出C3a的特异性和1至2%的生物活性。
生物活性

C3a (70-77) is an octapeptide corresponding to the COOH terminus of C3a, exhibits the specificity and 1 to 2% biologic activities of C3a.

IC50& Target

Complement system[1]

体外研究
(In Vitro)

The direct interaction of C3a(70-77) with human mononuclear leukocytes in culture results in a concentration-dependent inhibition of the generation of LIF evoked by mitogens and by the antigen SK-SD. The extent of suppression of LIF generation by C3a(70-77) is significant at concentrations of 10-7M or higher and exceeds 75% at 10-6M, irrespective of the stimulus[1].
C3a (70-77) induces histamine release and degranulation of rat mast cells, promotes contraction of guinea pig ileal tissue, and enhances vascular permeability in human skin. C3a (70-77) selectively desensitizes ileal smooth muscle to C3a but not to human C5a, a related anaphylatoxin. Conversely, C3a-(70-77) is unable to contract ileal smooth muscle pretreated with natural C3a. This cross-desensitization indicates a specific interaction of C3a (70-77) with cellular C3a binding sites[2].

分子量

823.94

Formula

C35H61N13O10

CAS 号

63555-63-5

Sequence

Ala-Ser-His-Leu-Gly-Leu-Ala-Arg

Sequence Shortening

ASHLGLAR

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.