| CAS NO: | 23981-47-7 |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| Cas No. | 23981-47-7 |
| 别名 | 6-甲基萘乙酸,6-MNA |
| 化学名 | 6-methoxy-2-naphthaleneacetic acid |
| Canonical SMILES | COC1=CC(C=CC(CC(O)=O)=C2)=C2C=C1 |
| 分子式 | C13H12O3 |
| 分子量 | 216.2 |
| 溶解度 | ≤55mg/ml in ethanol;24mg/ml in DMSO;25mg/ml in dimethyl formamide |
| 储存条件 | Room temperature |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 6-methoxy Naphthalene Acetic Acid is a competitive and non-selective COX inhibitor with Ki values of 21 and 19 μM for ovine COX-1 and -2, respectively [1][2][3]. Cyclooxygenase (COX), also known as prostaglandin-endoperoxide synthase (PTGS, PGHS), is an enzyme responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin. COX-1 is the constitutive isoform and is mainly responsible for the synthesis of cytoprotective prostaglandins in the gastrointestinal tract (GI) and of the proaggregatory thromboxane in blood platelets. COX-2 is inducible and short-lived that is stimulated by endotoxin, cytokines, and mitogens. COX-2 plays important roles in prostaglandin biosynthesis in inflammatory cells the central nervous system [1][2]. 6-methoxy Naphthalene Acetic Acid (6-MNA) is a competitive and non-selective COX inhibitor with Ki values of 21 and 19 μM for ovine COX-1 and -2, respectively [1][2]. 6-MNA is a metabolite of nebumetome. 6-MNA inhibited human recombinant COX-1 and -2 with IC50 values of 70 and 20 μM, respectively [1]. References: |
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