(S)-BI-1001 (Compound 11) is an active S-enantiomer of BI-1001. (S)-BI-1001 exhibits antiviral potency againstHIV-1integrasewith anIC₅₀of 28 nM, anEC₅₀of 450 nM and aK_dof 4.7 μM^[1].

IC50: 28 nM (HIV-1 integrase)^[1]
EC50: 450 nM (HIV-1 integrase)^[1]
Kd: 4.7 μM (HIV-1 integrase)^[1]

The C3 substituent is critical to the binding of (S)-BI-1001 (Compound 11) to the CCD of integrase and makes two key contacts with the protein: (a) a bivalent hydrogen bonding interaction with protein backbone at residues E170 and H171, and (b) a van der Waals contact deep in the hydrophobic pocket via the methoxyl group. The quinoline scaffold lies flat on the surface of the protein partially covering residues 124 and 125 and makes productive contact with the methyl group of A128^[1].

420.68

C₁₉H₁₅BrClNO₃

957889-73-5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.