A12B4C3

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A12B4C3

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1005129-80-5

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

A12B4C3 是一种人多核苷酸激酶/磷酸酶 (hPNKP)抑制剂，IC₅₀为 0.06 μM。A12B4C3 对癌细胞具有抗增殖活性。A12B4C3 还能增加某些癌细胞的辐射敏感性。

生物活性

A12B4C3 is a potenthuman polynucleotide kinase/phosphatase (hPNKP)inhibitor with anIC₅₀value of 0.06 μM. A12B4C3 has antiproliferative activity againstcancercells. A12B4C3 can also enhance the radiosensitivity of certaincancercells^[1].

IC₅₀& Target

IC₅₀: 0.06 μM (hPNKP)^[1]

体外研究
(In Vitro)

A12B4C3 (0-10 μM) strongly inhibits hPNKP phosphatase activity^[1].
A12B4C3 (0-100 μM; 72 h) reduces A549 and MDA-MB-231 cell proliferation in a dose dependent manner^[1].
A12B4C3 (1 μM; 24 h) increases the radiosensitivity of A549 cells^[1].

Cell Proliferation Assay^[1]

Cell Line:	A549 and MDA-MB-231
Concentration:	0, 1, 5, 10, 50 and 100 μM
Incubation Time:	72 h
Result:	Reduced cell proliferation in a dose dependent manner, and up to ~50% at 100 μM.

Cell Proliferation Assay^[1]

Cell Line:	A549 and MDA-MB-231 (incubated with A12B4C3 for 2h then irradiated 0-10 Gy)
Concentration:	1 μM
Incubation Time:	24 h
Result:	Almost doubled the radiosensitivity of A549 cells.

分子量

534.65

Formula

C₃₀H₃₈N₄O₅

CAS 号

1005129-80-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.