Uric acid 是氧自由基(oxygen radical)的清除剂，是一种非常重要的抗氧化剂，有助于维持血压的稳定和抗氧化应激。Uric acid 能清除活性氧 (ROS)，如单线态氧和过氧亚硝酸盐，抑制脂质过氧化。
| 生物活性 | Uric acid, scavenger ofoxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid can removereactive oxygen species(ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation[1][2]. |
| IC50& Target | Human Endogenous Metabolite |
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体外研究
(In Vitro) | Uric acid (400 μM; 48 hours) protects Caco-2 cells from indomethacin-induced lipid peroxidation[2].
Co-treatment of cells with Indomethacin and Uric acid (200 μM IND plus 400 μM UA; 24 hours) significantly decreases ROS levels compared to those in cells incubated with indomethacin alone. Cell viability in Caco-2 cells treated with both Indomethacin and Uric acid (200 μM IND plus 400 μM UA; 24 hours) is higher than that in cells treated with indomethacin alone. Uric acid has a protective effect on indomethacin-induced intestinal cell changes through its antioxidant activity[2].
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体内研究
(In Vivo) | Uric acid (250 mg/kg; p.o.) ameliorates indomethacin-induced enteropathy[2].
Oral administration of uric acid decreased ROS accumulation in the ileum in a mouse model of indomethacin-induced enteropathy[2].
| Animal Model: | Eight-week-old male C57BL/6J mice[2] | | Dosage: | 250 mg/kg body weight | | Administration: | P.o. | | Result: | When mice treated with indomethacin were concurrently administered uric acid orally, ulcer areas were significantly reduced, in a uric acid dose-dependent manner. |
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| 结构分类 | - Ketones, Aldehydes, Acids
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | | Powder | -20°C | 3 years | | 4°C | 2 years | | In solvent | -80°C | 6 months | | -20°C | 1 month |
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| 溶解性数据 | In Vitro: H2O : 6.25 mg/mL(37.18 mM;Need ultrasonic) DMSO :< 1 mg/mL (ultrasonic)(insoluble or slightly soluble) 配制储备液 | 1 mM | 5.9485 mL | 29.7424 mL | 59.4849 mL | | 5 mM | 1.1897 mL | 5.9485 mL | 11.8970 mL | | 10 mM | 0.5948 mL | 2.9742 mL | 5.9485 mL |
*请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。 |
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