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NPC-15437(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NPC-15437(hydrochloride)图片
CAS NO:141774-20-1
包装与价格:
包装价格(元)
500μg电议
1mg电议
5mg电议

产品介绍
Cas No.141774-20-1
化学名(2S)-2,6-diamino-N-[[1-(1-oxotridecyl)-2-piperidinyl]methyl]-hexanamide, dihydrochloride
Canonical SMILESO=C(CCCCCCCCCCCC)N1CCCCC1CNC([C@@H](N)CCCCN)=O.Cl.Cl
分子式C25H50N4O2.2HCl
分子量511.6
溶解度DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): 1 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述 NPC-15437 is a selective protein kinase C (PKC) inhibitor (IC50 = 19 uM). It competitively inhibits phorbol ester- (Ki = 5 uM) and phosphatidylserine-induced (Ki = 12 uM) PKC activity but does not affect the activity of cAMP-dependent or Ca2+/calmodulin-dependent protein kinases. PKC signaling is involved in learning and memory, and when NPC-15437 was administered after Y maze training (0.1-10 mg/kg i.p.), it led to memory retention deficits in mice.