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Arazine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Arazine图片
CAS NO:135304-07-3
包装:5mg (27.2 mM * 500 μL in Methyl acetate)
市场价:3700元

产品名称
N-acetyl-S-farnesyl-L-Cysteine
产品介绍
Arazine (N-Acetyl-S-farnesyl-L-cysteine) 是 G 蛋白和 G 蛋白偶联受体 (G protein and G-protein coupled receptor) 信号传导的细胞渗透性调节剂。Arazine 可与异戊烯化的 G 蛋白或其受体位点竞争,成为异戊二烯基半胱氨酸甲基转移酶的底物。
生物活性

Arazine (N-Acetyl-S-farnesyl-L-cysteine) is a cell-permeable modulator ofG protein and G-protein coupled receptorsignaling. Arazine can be a a substrate for isoprenylcysteine methyltransferase by competing with prenylated G protein or its receptors site[1].

体外研究
(In Vitro)

Arazine (2 hours) inhibits ATPγS induced CXCL1, CXCL8 and CCL2 production as a dose-dependent manner in HMEC-1 cell[1].
Arazine (10–100 μM;8 hours) significantly affects the HMEC-1 cell viability as measured by trypan blue exclusion in HMEC-1 cell[1].

体内研究
(In Vivo)

Arazine (AFC) (2,000 μg/20 μl; applied on ear) produces a dose-dependent inhibition of the TPA-induced edema, with the maximal reduction of edema approaching 73%, with a 50% effective dose (ED50) of 55±12 μg/20 μl[1].

Animal Model:TPA-induced ear acute inflammation in mouse[1]
Dosage:2000 μg/20 μl
Administration:2000 μg/20 μl; Applied on ear
Result:Inhibited ear edema, as measured by ear weight.
分子量

367.55

性状

Liquid

Formula

C20H33NO3S

CAS 号

135304-07-3

中文名称

N-乙酰基-S-法呢基-L-半胱氨酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Solution, -20°C, 2 years