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P8RI
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
P8RI图片
CAS NO:2147724-76-1
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品名称
D-P8RI
产品介绍
P8RI (D-P8RI) 是CD31的模拟肽和CD31激动剂。P8RI 与 CD31 外结构域的膜旁氨基酸序列结合,通过恢复 CD31 抑制途径显示出免疫抑制作用。
生物活性

P8RI (D-P8RI) is a biomimetic peptide of CD31 and aCD31agonist. P8RI binds to the juxtamembrane amino acid sequence of the ectodomain of CD31, shows an immunosuppressive effect through restoration of the CD31 inhibitory pathway[1][2].

体外研究
(In Vitro)

P8RI (D-P8RI) was designed as a retro-inverso peptide with all-D-amino acids allowing to maintain bioactivity and to confer resistance towards plasma proteases[1].

体内研究
(In Vivo)

P8RI (2.5 mg/kg; s.c.; daily from 7 to 28 after the occurrence of ADIM) prevents aneurysmal transformation by promoting the resolution of intramural hematoma and the production of collagen in dissected aortas in vivo, associated with enrichment of M2 macrophages at the site of injury[3].

Animal Model:Apo E-/-mice (male, 28-week-old) implanted with Ang II-releasing pumps (a model of experimental acute aortic dissection and intramural hematoma (ADIM))[3]
Dosage:2.5 mg/kg
Administration:Subcutaneous injection; daily from 7 to 28 (after the implantation of the osmotic pump delivering Ang II)
Result:Aneurysmal transformation was significantly reduced.
分子量

1016.24

性状

Solid

Formula

C51H77N13O9

CAS 号

2147724-76-1

Sequence Shortening

KWPALFVR

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder-80°C2 years
-20°C1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O : 100 mg/mL(98.40 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM0.9840 mL4.9201 mL9.8402 mL
5 mM0.1968 mL0.9840 mL1.9680 mL
10 mM0.0984 mL0.4920 mL0.9840 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: PBS

    Solubility: 100 mg/mL (98.40 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在本网站选购。