CAS NO: | 2207-75-2 |
包装 | 价格(元) |
10 mM * 1 mL in Water | 电议 |
500mg | 电议 |
5 g | 电议 |
10 g | 电议 |
50 g | 电议 |
生物活性 | Potassium oxonate is an inhibitor of uricase, inhibits the phosphorylation of 5-FU to 5-fluorouridine-5'-monophosphate catalyzed by pyrimidine phosphoribosyl-transferase in a different manner from allopurinol in cell-free extracts and intact cells in vitro. IC50 value: Target: On p.o. administration of 5-FU (2 mg/kg) and a potent inhibitor of 5-FU degradation to Yoshida sarcoma-bearing rats, oxonic acid (10 mg/kg) was found to inhibit the formation of 5-fluorouridine-5'-monophosphate from 5-FU and its subsequent incorporation into the RNA fractions of small and large intestine but not of tumor and bone marrow tissues [1]. Oxonic acid diet increased plasma uric acid by 80-90 micromol/l, while blood pressure was elevated only in hyperuricemic 5/6 nephrectomy rats (18 mmHg) [2]. | ||||||||||||||||
分子量 | 195.17 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C4H2KN3O4 | ||||||||||||||||
CAS 号 | 2207-75-2 | ||||||||||||||||
中文名称 | 氧嗪酸钾 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: H2O : 5 mg/mL(25.62 mM;ultrasonic and warming and heat to 80℃) DMSO :< 1 mg/mL (ultrasonic;warming;heat to 80℃)(insoluble or slightly soluble) 配制储备液
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