trans-urocanic acid (trans-UCA) 是一种天然表皮成分,可在体外抑制人自然杀伤细胞 (NK) 活性。
Cas No. | 3465-72-3 |
别名 | 尿刊酸,(E)-Urocanic acid; trans-UCA |
Canonical SMILES | OC(/C=C/C1=CN=CN1)=O |
分子式 | C6H6N2O2 |
分子量 | 138.1 |
溶解度 | DMF: 3 mg/ml,DMSO: 15 mg/ml,PBS (pH 7.2): 0.3 mg/ml |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | trans-Urocanic acid is a major epidermal chromophore for the immunosuppressive effects of UV radiation that is produced in mammalian stratum corneum by the action of histidine ammonialyase on L-histidine. It contributes to the acidification of the surface of the stratum corneum, and its function has been proposed as that of an endogenous sunscreen, endowing a low-level of protection (SPF ~ 1.5) against UV-induced DNA damage and excessive keratinocyte apoptosis. Upon UVB exposure, trans-urocanic acid is converted to the cis isomer, which is known to activate regulatory T cells. |