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trans-Urocanic Acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
trans-Urocanic Acid图片
CAS NO:3465-72-3
包装与价格:
包装价格(元)
1g电议
5g电议

产品介绍
trans-urocanic acid (trans-UCA) 是一种天然表皮成分,可在体外抑制人自然杀伤细胞 (NK) 活性。
Cas No.3465-72-3
别名尿刊酸,(E)-Urocanic acid; trans-UCA
Canonical SMILESOC(/C=C/C1=CN=CN1)=O
分子式C6H6N2O2
分子量138.1
溶解度DMF: 3 mg/ml,DMSO: 15 mg/ml,PBS (pH 7.2): 0.3 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

trans-Urocanic acid is a major epidermal chromophore for the immunosuppressive effects of UV radiation that is produced in mammalian stratum corneum by the action of histidine ammonialyase on L-histidine. It contributes to the acidification of the surface of the stratum corneum, and its function has been proposed as that of an endogenous sunscreen, endowing a low-level of protection (SPF ~ 1.5) against UV-induced DNA damage and excessive keratinocyte apoptosis. Upon UVB exposure, trans-urocanic acid is converted to the cis isomer, which is known to activate regulatory T cells.