Promegestone (R-5020), a progestin, is a potentprogesterone receptor(PR)agonist. Promegestone has the potential for endocrine regulation andcancerresearch^[1].

Promegestone (R-5020; 1 nM) is efficient ligand with a full agonist response profile and a low EC₅₀of 0.33 nM) in HELN-hPR while it only partially induced luciferase activity in U2OS-zfPR (EC₅₀=1.93 nM)^[1].
Promegestone is inactive in HELN cells that express luciferase but no functional receptor^[1].
Promegestone (10 nM) robustly stimulatesSLC37A2expression in cells expressing SUMO-deficient PR, but not in cells expressing WT PR in T47D cell models^[3].

Promegestone (R-5020; 8 mg/kg; intramuscularly)-treated pregnant mice on day 18 postbreeding has the least deterioration in extracellular collagen (lowest OD) and highest cell density compared to other groups on the day before birth^[2].

326.47

C₂₂H₃₀O₂

34184-77-5

普美孕酮

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