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Promegestone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Promegestone图片
CAS NO:34184-77-5
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
普美孕酮
R-5020
Surgestone
产品介绍
Promegestone (R-5020) 是一种孕激素,是一种有效的孕酮受体 (PR) 激动剂。Promegestone 具有内分泌调节和癌症研究的潜力。
生物活性

Promegestone (R-5020), a progestin, is a potentprogesterone receptor(PR)agonist. Promegestone has the potential for endocrine regulation andcancerresearch[1].

体外研究
(In Vitro)

Promegestone (R-5020; 1 nM) is efficient ligand with a full agonist response profile and a low EC50of 0.33 nM) in HELN-hPR while it only partially induced luciferase activity in U2OS-zfPR (EC50=1.93 nM)[1].
Promegestone is inactive in HELN cells that express luciferase but no functional receptor[1].
Promegestone (10 nM) robustly stimulatesSLC37A2expression in cells expressing SUMO-deficient PR, but not in cells expressing WT PR in T47D cell models[3].

体内研究
(In Vivo)

Promegestone (R-5020; 8 mg/kg; intramuscularly)-treated pregnant mice on day 18 postbreeding has the least deterioration in extracellular collagen (lowest OD) and highest cell density compared to other groups on the day before birth[2].

分子量

326.47

Formula

C22H30O2

CAS 号

34184-77-5

中文名称

普美孕酮

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.