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Ferutinin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ferutinin图片
CAS NO:41743-44-6
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Ferutinin 是一种天然萜类化合物,是一种雌激素受体ERα激动剂和雌激素ERβ受体激动剂/拮抗剂,IC50分别为 33.1 nM 和 180.5 nM。Ferutinin 作为一种产电 Ca2+离子载体,可增加脂质双层膜、线粒体的钙通透性。Ferutinin 具有雌激素、抗肿瘤、抗菌和抗炎活性。
生物活性

Ferutinin, a natural terpenoid compound, is anestrogen receptorERαagonist andestrogen ERβ-receptoragonist/antagonist withIC50s of 33.1 nM and 180.5 nM, respectively. Ferutinin acts as an electrogenic Ca2+-ionophore that increases calcium permeability of lipid bilayer membranes, mitochondria. Ferutinin possesses estrogenic, antitumor, antibacterial and antiinflammatory activities[1][2].

IC50& Target[1]

ERα

33.1 nM (IC50)

ERβ

180.5 nM (IC50)

体外研究
(In Vitro)

Ferutinin manifested antiproliferative activity, inducing apoptosis in several cell types: MCF-7 estrogen-dependent cancer cells, leukemia T-cell line (Jurkat), human and mouse colon carcinoma cells (Caco-2, CT26, HT29), as well as bladder (TCC) cancer cells. Ferutinin potentiates bone mineralization, and is proposed to be used as an antiosteoporosis phytoestrogen[2].
Ferutinin considerably increases the permeability of artificial and cellular membranes to Ca2+-ions and produces apoptotic cell death in different cell lines in a mitochondria-dependent manner. Ferutinin alone (10-60 μM) also dose-dependently dissipated membrane potential. In the presence of Ca2+-ions, Ferutinin (10-60 μM) induces considerable depolarization of the inner mitochondrial membrane[2].

分子量

358.47

Formula

C22H30O4

CAS 号

41743-44-6

结构分类
  • Terpenoids
  • Sesquiterpenes
来源
  • Plants
  • Umbelliferae
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.