LY117018, a Raloxifene analog, is a selectiveestrogen receptormodulator. LY117018 exerts antiproliferative effects on breastcancercell lines^[1][2].

LY117018 (0.01-1000 nM; 24 hours) at lower concentrations (0.01-10 nM) caused an E2-like increase in p53 levels when compared to its effects on cells grown in the stripped medium. At a higher concentration of LY117018 (1 μM), the level of p53 appeared to decline. Treatment with 1 μM LY117018 resulted in a predominantly hypophosphorylated pRb. At lower concentrations, LY117018 did not block E2-induced pRb phosphorylation^[1].
LY117018 (1 μM; 96 hours) inhibits MCF-7 cells proliferation with an IC₅₀of 1 μM^[2].
LY117018 suppresses oxidative stress-induced endothelial cell apoptosis through activation of ERK1/2 signaling pathway^[3].

459.56

C₂₇H₂₅NO₄S

63676-25-5

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