ACP-105 is an orally available, selective amd potentandrogen receptormodulator (SARM), withpEC₅₀sof 9.0 and 9.3 for AR wild type and T877A mutant, respectively.

pEC50: 9.0 (AR wild type), 9.3 (AR T877A mutant)^[1].

ACP-105 is an orally available, selective amd potent androgen receptor modulator (SARM), with pEC₅₀s of 9.0 and 9.3 for AR wild type and T877A mutant, respectively. The half-lives of ACP-105 (compound 1) in human hepatocytes is measured and found to be 5.0 h^[1].

ACP-105 enhances freezing in both sham-irradiated and irradiated mice (effect of ACP-105: F=5.44; p=0.028). For MAP-2 immunoreactivity in the cortex of sham-irradiated mice, there is a brain area×ACP-105 interaction (F=6.655; p=0.0027). While ACP-105 reduces MAP-2 immunoreactivity in the sensorymotor cortex, there is a trend towards increased MAP-2 immunoreactivity in the enthorhinal cortex^[2].

290.79

Solid

C₁₆H₁₉ClN₂O

899821-23-9

Room temperature in continental US; may vary elsewhere.

DMSO : ≥ 103 mg/mL(354.21 mM)

*"≥" means soluble, but saturation unknown.

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