CAS NO: | 1203490-23-6 |
包装 | 价格(元) |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Ralaniten (EPI-002) is a potent and orally active antagonist of theandrogen receptor-N-terminal domain (AR-NTD). Ralaniten inhibits AR transcriptional activity, withIC50of 7.4 μM. Ralaniten can be used for the research of castration-resistant prostatecancer(CRPC)[1][2]. | ||||||||||||||||
IC50& Target | IC50: 7.4 μM (AR-NTD)[1] | ||||||||||||||||
体外研究 (In Vitro) | EPI-002 (5-35 μM; 2-3 days) reduces AR-dependent proliferation of LNCaP cells, and has no effect on the viability of PC3 human prostate cancer cells that do not express functional AR[1]. | ||||||||||||||||
体内研究 (In Vivo) | EPI-002 (100 mg/kg; p.o. twice daily for 28 days) inhibits the VCaP tumor growth in castrated mice[1].
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分子量 | 394.89 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C21H27ClO5 | ||||||||||||||||
CAS 号 | 1203490-23-6 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 100 mg/mL(253.24 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
*以上所有助溶剂都可在本网站选购。 |