Cl-4AS-1

立即咨询

Cl-4AS-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

188589-66-4

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Cl-4AS-1 是一种有效的类固醇雄激素受体(AR)激动剂 (IC₅₀为 12 nM)，也是 5α- 还原酶 I 型和 II 型的抑制剂 (IC₅₀分别为 6 和 10 nM)。

生物活性

Cl-4AS-1, a potent steroidalandrogen receptor(AR)agonist (IC₅₀= 12 nM), is also an inhibitor of 5α-reductase types I and II (IC50 = 6 and 10 nM, respectively)^[1]^[2].

IC₅₀& Target

IC50: 12 nM (androgen receptor); 6 nM (5α-reductase types I); 10 nM (5α-reductase types II)^[1]^[2]

体外研究
(In Vitro)

Cl-4AS-1 suppresses MMP-1 promoter activity in 22Rv1 human prostate cancer cells^[1].
Cl-4AS-1 (10 μM) effectively promotes the AR N/C interaction, with an average maximal activity of 35.3%^[1].

体内研究
(In Vivo)

Cl-4AS-1 produces no significant reduction in prostate weight in intact animals and in castrates rats caused a significant increase of ventral prostate weight^[1].

Animal Model:	ORX rats^[1]
Dosage:	10 mg/kg
Administration:	I.s.; 7 days
Result:	Effect of Cl-4AS-1 on prostate and seminal vesicle growth.

分子量

441.01

Formula

C₂₆H₃₃ClN₂O₂

CAS 号

188589-66-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.