ALK5-IN-33

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ALK5-IN-33

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2785430-89-7

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

ALK5-IN-33 (Compound EX-10) 是一种选择性的、具有口服活性的ALK-5抑制剂，IC₅₀不高于 10 nM。

生物活性

ALK5-IN-33 (Compound EX-10) is a selective, orally activeALK-5inhibitor with anIC₅₀≤10 nM^[1].

IC₅₀& Target

ALK5

≤10 nM (IC₅₀)

ALK2

体外研究
(In Vitro)

ALK-IN-33 (Compound EX-10) shows a high efficiency by inducing a full inhibition (max PIN greater than 75) of TGF-β1 mediated alpha-SMA expression, in at least two donors^[1].

体内研究
(In Vivo)

ALK-IN-33 (Compound EX-10) (10-100 mg/kg; i.g.; once) reduces the phospho SMAD2 levels in a dose dependent fashion in A549 xenograft model in mice^[1].

Animal Model:	Female athymic nude mice, A549 xenograft model^[1]
Dosage:	10, 50, 75 and 100 mg/kg
Administration:	Oral gavage, once
Result:	Reduced the phospho SMAD2 levels (p-SMAD2) in a dose dependent fashion.

分子量

413.48

Formula

C₂₃H₂₃N₇O

CAS 号

2785430-89-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.