您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > PKA inhibitor fragment(6-22)amide
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
PKA inhibitor fragment(6-22)amide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:121932-06-7
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
PKI-(6-22)-amide
产品介绍
PKA Inhibitor Fragment (6-22) amide 是 cAMP 依赖性蛋白激酶A (PKA)的抑制剂,Ki值为 2.8 nM。PKA Inhibitor Fragment (6-22) amide 可显着逆转小鼠低水平的吗啡缓解疼痛的感受。
生物活性

PKA InhibitorFragment (6-22) amide is an inhibitor of cAMP-dependentprotein kinase A (PKA), with aKiof 2.8 nM.PKA InhibitorFragment (6-22) amide can significantly reverse low-level morphine antinociceptive tolerance in mice[1][2].

IC50& Target

PKA

2.8 nM (Ki)

分子量

1868.06

Formula

C80H130N28O24

CAS 号

121932-06-7

Sequence Shortening

TYADFIASGRTGRRNAI-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

 ContentsAssign value
Acidic amino acidAsp (D), Glu (E), and the C-terminal -COOH.-1
Basic amino acidArg (R), Lys (K), His (H), and the N-terminal -NH2+1
Neutral amino acidGly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)0

3.  Recommended solution:

Overall charge of peptideDetails
Negative (<0)1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.